Organic Chemistry

The Research Group of Organic Chemistry (ORGC) is active in the fields of bioorganic and medicinal chemistry. The lab mainly focuses on the identification of relationships between structure and activity/transport properties of various bioactive peptides and peptidomimetics. The research unit has established a long-standing tradition in the preparation of modified peptides. Special attention is dedicated to conformational constraints and the derivatization of biomolecules by means of transition metal-catalyzed coupling reactions. As such, the group aims to contribute to the research domain of protein-protein interaction modulation, the development of (bioorthogonal) reactions that can be utilized with biomolecule substrates. One of the main research lines within the group focuses on peptide-based biomaterials for tissue engineering and controlled-drug release. Moreover, the group works on multicomponent reactions. Multicomponent reactions represent one of the most powerful approaches for combinatorial chemistry and diversity-oriented synthesis. They present a huge potential in the development of drug discovery methodology and biological probes. Finally, access to medium-sized ring systems (9- to 15-membered rings) and macrocyclics is currently and thoroughly being investigated.


  • (Cyclic) Peptides and Peptidomimetics
  • Modulation of Protein-Protein Interactions (PPIs)
  • Peptide probes for in vivo imaging
  • Heterocyclic Chemistry
  • Transition metal-catalyzed reactions and (bioorthogonal) conjugation
  • Synthetic Methodology
  • Fragment-based drug design


Vrije Universiteit Brussel
Research Group of Organic Chemistry
Departments of Bioengineering Sciences and Chemistry

Pleinlaan 2 - 1050 Brussels - Belgium

Steven Ballet, Associate Professor Bioorganic Chemistry
[T] +32 (0)2 629 32 92