Structural Biology Brussels (SBB)

The Structural Biology Brussels Lab (SBB), headed by Jan Steyaert, was founded by Lode Wyns in the seventies at the Vrije Universiteit Brussel and is part of one of the Flanders Institute for Biotechnology (VIB) departments, a Flanders-based life sciences research center of excellence. Situated in Brussels, a multidisciplinary team of international researchers combines extensive expertise in protein chemistry, biophysics and molecular biology. The SBB lab masters technologically advanced techniques such as genetic engineering, protein purification, enzymology, calorimetry, crystallography, surface plasmon resonance, atomic force microscopy, X-ray crystallography and Nuclear Magnetic Resonance (NMR). Major research interests include Biomedical targets, Structural enzymology, Bacterial adhesion, Toxinantitoxin systems, Microgravity research and Biomolecular NMR. Translational research is intrinsic to its programs, with possible applications in medicine. The SBB lab was involved in the pioneering work in which Brian Kobilka’s research team revealed the structure and inner workings of an important family of G-protein–coupled receptors.

This led to several publications in "Nature":

• Structure of a nanobody-stabilized active state of the ß2 adrenoceptor
NATURE, 469, 175-80, 2011
• Crystal structure of the beta2 adrenergic receptor-Gs protein complex 
NATURE, 477, 549-55, 2011

Read the latest article Published in Nature on March 20, 2013:
Conformational biosensors reveal GPCR signalling from endosomes

Download the SBB  brochure

Find out about their spin-offs Agrosavfe & Ablynx.


Vrije Universiteit Brussel
Structural Biology Brussels

Building E – Room 4.6
Pleinlaan 2 | 1050 Brussels | Belgium

Director: Professor Dr. ir. Jan Steyaert
[T] +32 (0)2 629 19 31