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Confo Therapeutics is a drug discovery company building a unique pipeline of GPCR targeted therapeutics addressing unmet medical need. The company was founded in 2015 as a spin-off from the VUB and VIB and capitalizes on the ConfoBody™  technology developed by Prof. Jan Steyaert at VIB Structural Biology Research Center, Vrije Universiteit Brussel.

ConfoBodies are camel single domain antibodies that stabilize distinct druggable conformers of flexible protein targets and reveal previously inaccessible structural features. Confo Therapeutics uses these ConfoBody™-stabilized functional conformations of GPCRs as a superior starting point for drug discovery empowering the discovery of novel agonists for better therapeutic intervention.

Confo Therapeutics


  • 2015: founded by the VUB and VIB
  • 2017: drug discovery collaboration with Roche
  • 2019:
    - raises €30 million in Series A financing
    - €1.7 million grant from VLAIO to target an orphan indication
    - drug discovery collaboration with DyNAbind
  • 2022: Confo Therapeutics doses first subjects in Phase 1 clinical trial of CFTX-1554 for the treatment of neuropathic pain
Confo Therapeutics


Confo Brussels
Pleinlaan 2
Building E, 7th Floor, Room E7.6
B-1050 Brussels