The liver regulates numerous physiological processes essential for human health, such as lipid and cholesterol homeostasis and the breakdown of xenobiotic compounds including pharmaceuticals. As such, any alterations in liver cell biology provoked by genetic factors, exposure to pathogens or xenobiotics, or even due to an unhealthy lifestyle, can have serious health consequences that significantly contribute to global morbidity and mortality burdens. This drives the need to understand the breadth of liver pathologies, both inherited (through genetic factors) or induced (in response to toxicants or unhealthy lifestyle) to uncover how to avoid or treat them. This goal requires the implementation of innovative preclinical models that allow more accurate predictive investigations of human liver cell biology, pathology and toxicity.
In answer to this need, the research team IVTD, builds on more than 30 years of experience in the development of in vitro liver models for pharmaco-toxicological and liver disease modelling purposes. IVTD’s proprietary hSKP-HPC (or HepaSTAR) model, is a novel in vitro model derived from human, post-natal skin stem cells proven in mechanistic investigations of chronic and acute liver injury caused by either drugs, chemicals or by disease.
HepaSTARs can be applied to: