Important new clues for future cancer immunotherapies
Human glioblastoma tumors are aggressive hard-to-treat brain cancers that have a high unmet need for new treatment options. A team of researchers led by Prof. Kiavash Movahedi and Prof. Jo Van Ginderachter (VIB-VUB), in collaboration with colleagues from VIB, VUB, and KU Leuven, have mapped the immune landscape in these glioblastoma tumors. Their results provide insights into the multifaceted role of glioblastoma-associated macrophages. This important class of immune cells infiltrates the tumors and promotes disease progression. As macrophages form an important therapeutic target for glioblastoma, the new findings provide a basis for developing new immunotherapeutic approaches for this disease. The findings were published in Nature Neurosciences.